o-succinylbenzoic acid synthase

<enzyme> E coli enzyme; with shchc synthase catalyses formation of o-succinylbenzoic acid from isochorismic acid and alpha-ketoglutarate in presence of thiamine pyropyrophosphate; succinic semialdehyde anion is formed by decarboxylation of alpha-ketoglutarate by thiamine pyrophosphate; anion then attacks isochorismic acid, initiating aromatization with elimination of pyruvate and h2o

Registry number: EC 4.1.99.-

Synonym: ortho-succinylbenzoic acid synthase, osb synthase, 2-succinylbenzoic acid synthase

(26 Jun 1999)


Terms mentioned in text: enzyme, enzyme, synthase, catalyses, formation, acid, alpha-ketoglutarate, thiamine, succinic, semialdehyde, anion, formed, decarboxylation, alpha, thiamine pyrophosphate, attacks, elimination, pyruvate, acid, synthase
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