O-phosphocholine

(CH3)3N+-CH2 CH2-OPO3 H-; choline O-phosphate;important in choline metabolism, e.g., as in cytidinediphosphocholine and in the biosynthesis of lecithins.

Synonym: O-phosphocholine, phosphorylcholine.

Phosphocholine cytidylyltransferase, an enzyme that catalyses the reaction of phosphocholine with CTP to form pyrophosphate and CDP-choline; the rate-limiting step of lecithin biosynthesis; the cytosolic form of the enzyme is inactive (a phosphorylated form of the enzyme).

Phosphocholine diacylglycerol transferase, an enzyme in lecithin biosynthesis that catalyses the reaction of 1,2-diacylglycerol with CDP-choline to form CMP and phosphatidylcholine.

(05 Mar 2000)


Terms mentioned in text: choline, phosphate, metabolism, biosynthesis, lecithins, o-phosphocholine, phosphorylcholine, enzyme, catalyses, reaction, ctp, pyrophosphate, cdp-choline, rate-limiting step, lecithin, biosynthesis, cytosolic, inactive, diacylglycerol, transferase, enzyme, lecithin, biosynthesis, catalyses, reaction, cdp-choline, cmp, phosphatidylcholine
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